1424272-67-2Relevant articles and documents
Radiosynthesis of 18F-labeled N-desmethyl-loperamide analogues for prospective molecular imaging radiotracers
Bao, Xiaofeng,Liu, Duliang
, p. 1412 - 1415 (2013/04/23)
A simple procedure for preparing fluoroethyl-N-desmethyl-loperamide 4 and its analogue 5 was developed. Standard compound 4 was synthesized in useful yields for radiolabeling analysis. [N-Ethyl-18F]N-desmethyl-loperamide, 3, was rapidly and efficiently labeled with no-carrier added fluorine-18 (t 1/2 = 109.7 min) by treatment of readily prepared [ 18F]1-bromo-2-fluoro ethane with a N-desmethyl-loperamide precursor at a consistent 7% radiochemical yield. This procedure was also adapted to the radiosynthesis of 3 by [18F]ethylene tosylate, but at a lower 3% radiochemical yield. Copyright