14243-43-7

Basic information

• Product Name: Gold, (benzenethiolato)(triethylphosphine)-
• CAS NO: 14243-43-7
• Molecular Formula: C12H20AuPS
• Molecular Weight: 424.297
• Mol File: 14243-43-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Gold, (benzenethiolato)(triethylphosphine)-(CAS DataBase Reference)
• NIST Chemistry Reference: Gold, (benzenethiolato)(triethylphosphine)-(14243-43-7)
• EPA Substance Registry System: Gold, (benzenethiolato)(triethylphosphine)-(14243-43-7)

Safety Data

• Hazardous Substances Data: 14243-43-7(Hazardous Substances Data)

Upstream product

• 554-70-1 triethylphosphine 
• 91840-14-1 2,3,4,6-tetra-O-acetyl-1-thio-β-D-gluco-pyranosato-S-(triethylphosphane)gold 
• 108-98-5 thiophenol 
• 15529-90-5 (triethylphosphine)chlorogold(I) 

Downstream Products

• 65583-79-1 bis-(triethylphosphine)gold(I) chloride 
• 882-33-7 diphenyldisulfane 
• 91840-14-1 2,3,4,6-tetra-O-acetyl-1-thio-β-D-gluco-pyranosato-S-(triethylphosphane)gold 
• 108-98-5 thiophenol 

Relevant articles and documents

GOLD COMPOSITIONS AND METHODS OF USE THEREOF

Gold compounds and pharmaceutically acceptable salts thereof are disclosed. Certain compounds and salts are active as antibacterial, antifungal, and/or anti-parasitic agents. The disclosure provides pharmaceutical compositions containing the gold compounds. Methods of using the gold compounds to treat bacterial infections are disclosed.

Reactivity of auranofin with selenols and thiols - Implications for the anticancer activity of gold(I) compounds

The enzyme thioredoxin reductase (TrxR) is attracting much interest as a potential target for cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to inhibition by electrophilic molecules, including the AuI complex auranofin [2,3,4,6-tetra-O-acetyl-1-thio- β-D-glucopyranosato-S-(triethylphosphane)gold]. The reactions between auranofin and models of thiol and selenol nucleophiles present in TrxR (PhSH and PhSeH) have been investigated in chloroform and methanol by means of 1H, 31P, and 77Se NMR spectroscopy. In chloroform, auranofin undergoes ligand substitution of the tetraacetylthioglucose moiety by a PhS or PhSe group. The reaction is reversible in both cases, but it is characterized by widely different equilibrium constants (ca. 1 for S and at least 103 for Se). In polar solvents, such as methanol, the reaction is more complex, and the phosphane moiety also undergoes ligand exchange. Some features have been clarified through the investigation of Et3PAuCl. The elementary processes involved have been characterized by DFT calculations. Copyright