65583-79-1 Usage
Uses
Used in Organic Synthesis:
Bis(triethylphosphine)gold chloride is used as a catalyst for various organic synthesis reactions, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. Its high stability and reactivity make it valuable in this application.
Used in Preparation of Gold Nanoparticles:
Bis(triethylphosphine)gold chloride is used as a precursor in the preparation of gold nanoparticles. These nanoparticles have potential applications in various fields, including catalysis, sensing, and medicine.
Used in Cross-Coupling Reactions:
Bis(triethylphosphine)gold chloride is used as a catalyst in cross-coupling reactions, which are important for the formation of complex organic molecules. Its use in this application contributes to the advancement of synthetic chemistry.
Used in Medicinal Chemistry and Bioconjugation:
Bis(triethylphosphine)gold chloride has potential applications in medicinal chemistry and bioconjugation. Its unique properties and reactivity make it a promising candidate for the development of new drugs and bioconjugate systems.
Overall, bis(triethylphosphine)gold chloride plays a crucial role in advancing research and development in the field of synthetic chemistry, with applications in various industries, including pharmaceuticals, materials science, and nanotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 65583-79-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,5,8 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65583-79:
(7*6)+(6*5)+(5*5)+(4*8)+(3*3)+(2*7)+(1*9)=161
161 % 10 = 1
So 65583-79-1 is a valid CAS Registry Number.
InChI:InChI=1/2C6H15P.Au.3ClH/c2*1-4-7(5-2)6-3;;;;/h2*4-6H2,1-3H3;;3*1H/q;;+3;;;/p-3
65583-79-1Relevant academic research and scientific papers
Reactivity of auranofin with selenols and thiols - Implications for the anticancer activity of gold(I) compounds
Di Sarra, Francesca,Fresch, Barbara,Bini, Riccardo,Saielli, Giacomo,Bagno, Alessandro
, p. 2718 - 2727 (2013/07/11)
The enzyme thioredoxin reductase (TrxR) is attracting much interest as a potential target for cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to inhibition by electrophilic molecules, including the AuI complex auranofin [2,3,4,6-tetra-O-acetyl-1-thio- β-D-glucopyranosato-S-(triethylphosphane)gold]. The reactions between auranofin and models of thiol and selenol nucleophiles present in TrxR (PhSH and PhSeH) have been investigated in chloroform and methanol by means of 1H, 31P, and 77Se NMR spectroscopy. In chloroform, auranofin undergoes ligand substitution of the tetraacetylthioglucose moiety by a PhS or PhSe group. The reaction is reversible in both cases, but it is characterized by widely different equilibrium constants (ca. 1 for S and at least 103 for Se). In polar solvents, such as methanol, the reaction is more complex, and the phosphane moiety also undergoes ligand exchange. Some features have been clarified through the investigation of Et3PAuCl. The elementary processes involved have been characterized by DFT calculations. Copyright
