142439-65-4

Basic information

• Product Name: (2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE
• Synonyms: (2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE;(2-chloro-5-nitro-phenyl)-morpholin-4-yl-methanone;(2-chloro-5-nitrophenyl)-morpholin-4-ylmethanone;4-(2-chloro-5-nitrobenzoyl)morpholine
• CAS NO: 142439-65-4
• Molecular Formula: C₁₁H₁₁ClN₂O₄
• Molecular Weight: 270.67
• Mol File: 142439-65-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE(142439-65-4)
• EPA Substance Registry System: (2-CHLORO-5-NITROPHENYL)(MORPHOLINO)METHANONE(142439-65-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 142439-65-4(Hazardous Substances Data)

Usage

General Description

(2-chloro-5-nitrophenyl)(morpholino)methanone is a chemical compound that contains a chloro and nitro group attached to a phenyl ring, with a morpholino group attached to the methanone functional group. It is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. The chloro and nitro groups make it a useful starting material for the synthesis of other complex molecules, while the morpholino group can provide solubility and stability to the compound. Its versatile reactivity and potential biological activity make it an important intermediate in the development of new drugs and materials.

Upstream product

• 109-02-4 4-methyl-morpholine 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 110-91-8 morpholine 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 

Downstream Products

• 1533398-93-4 N-(4-chloro-3-(morpholine-4-carbonyl)phenyl)furan-2-carboxamide 
• 142439-52-9 N-<1--5-nitrobenzoyl>morpholide 
• 142439-50-7 {2-[Bis-(2-hydroxy-ethyl)-amino]-5-nitro-phenyl}-morpholin-4-yl-methanone 

Relevant articles and documents

SUBSTITUTED HETEROCYCLIC-PYRIDINONES AS HIV-1 NEF-HCK INHIBITORS

Disclosed are heterocyclic-pyridinone analogs that are capable of inhibiting Nef-Hck and methods of treating viral infections such as, for example, HIV-1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is

Substituted 2-phenylimidazopyridines: A new class of drug leads for human African trypanosomiasis

A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophenyl)oxazolopyridines as a starting point for hit-to-lead medicinal chemistry. A total of 110 analogues were prepared, which led to the identification of 64, a substituted 2-(3-aminophenyl)imidazopyridine. This compound showed antiparasitic activity in vitro with an EC50 of 2 nM and displayed reasonable druglike properties when tested in a number of in vitro assays. The compound was orally bioavailable and displayed good plasma and brain exposure in mice. Compound 64 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg. Given its potent antiparasitic properties and its ease of synthesis, compound 64 represents a new lead for the development of drugs to treat human African trypanosomiasis.