142465-27-8

Basic information

• Product Name: 1,4-diphenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

Upstream product

• 42076-13-1 3-phenyl-2-thio-4-oxo-3,4,5,6,7,8-hexahydrobenzothieno<2,3-d>pyrimidine 
• 98-88-4 benzoyl chloride 
• 142465-12-1 2-hydrazinyl-3-phenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 
• 27285-14-9 2-Hydroxy-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 60598-68-7 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid phenyl-amide 
• 134904-21-5 2-Chloro-3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 103-71-9 phenyl isocyanate 
• 27285-12-7 2-(3-phenyl-ureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 142465-16-5 2-(N-benzoyl)hydrazino-3-phenyl-6,7,8,9-tetrahydrobenzothieno<2,3-d>pyrimidin-4-one 

Relevant articles and documents

Title studies on the reaction of N-(3-carbethoxy-4,5,6,7-tetrahydrobenzo[b] thien-2-yl)-N′-phenylthiourea with hydrazine hydrate (Part 1)

(Chemical Equation Presented) The reaction of N-(3-carbethoxy-4,5,6,7- tetrahydrobenzo[b]thien-2-yl)-N′-phenylthiourea (1) with hydrazine hydrate in 1-butanol afforded a mixture of compounds 2, 3 and 4. Treatment of 3 and 4 with nitrous acid gave 6 and 8 respectively, while reactions of 3 with acetylacetone gave 7. Synthesis of tetracyclic compounds 9a-f and 11 from the reactions of 3 with ethyl orthoformate or appropriate acids, acid chloride, carbon disulphide and/or ethyl chloroformate. Also its reaction with isothiocyanate derivatives gave the corresponding thiosemicarbzides 12a,b which on, refluxing in alcoholic KOH gave the unexpected tetracyclic products 14a,b. Similarly the tetracyclic compounds 16a-e and 19 were obtained by cyclization of 4 and 18 respectively.

Synthesis of some triazolothienopyrimidin-5(4H)-ones

A series of hitherto unreported 1-(un)substituted-4-phenyltriazolothienopyrimidin-5(4H)-ones (8a-k) have been synthesized by the condensation of 2-hydrazino-3-phenylthienopyrimidin-4(3H)-ones (7a,b) with various one-carbon dono