142467-17-2

Upstream product

• 140659-85-4 2′-deoxy-5′-O-phthalimidonucleoside 
• 140659-86-5 5'-O-phthalimido-3'-t-butyldiphenylsilylthymidine 
• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 50-00-0 formaldehyd 
• 140659-87-6 5'-O-amino-3'-O-(tert-butyldiphenylsilyl)thymidine 

Downstream Products

• 140676-15-9 C₅₆H₆₁N₅O₉Si 
• 1054648-39-3 4-Amino-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyleneaminooxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 
• 195326-22-8 1-{(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione 
• 195326-42-2 4-Amino-1-{(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-[(N-methyl-aminooxy)-methyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Intermolecular Radical C-C Bond Formation: Synthesis of a Novel Dinucleoside Linker for Non-anionic Antisense Oligonucleosides

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction.The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.Key Words: antisense oligonucleotides, nonionic backbone, intermolecular radical reaction