140659-86-5

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 140659-85-4 2′-deoxy-5′-O-phthalimidonucleoside 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 146557-55-3 2′-deoxy-5′-O-phthalimidouridine 
• 50-89-5 thymidine 

Downstream Products

• 142467-17-2 5'-O-(methyleneamino)-3'-(t-butyldiphenylsilyl)thymidine 
• 140659-91-2 C₅₇H₆₃N₅O₉Si 
• 161277-51-6 C₅₆H₅₉N₅O₉Si 
• 140659-93-4 C₄₃H₄₉N₅O₁₁ 
• 140676-15-9 C₅₆H₆₁N₅O₉Si 
• 140659-87-6 5'-O-amino-3'-O-(tert-butyldiphenylsilyl)thymidine 

Relevant academic research and scientific papers

Intermolecular Radical C-C Bond Formation: Synthesis of a Novel Dinucleoside Linker for Non-anionic Antisense Oligonucleosides

An efficient, stereoselective synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-NH-O-5'-T) 1 has been accomplished via an intermolecular radical reaction.The new dimer and methodology is useful for the development of backbone modified antisense oligonucleosides.Key Words: antisense oligonucleotides, nonionic backbone, intermolecular radical reaction

Backbone modified oligonucleotide analogs

Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique