142479-00-3

Upstream product

• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 141018-37-3 (3aS,8aR)-2,2-dimethyl-3-(3-phenylpropanoyl)-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazole 
• 63-91-2 L-phenylalanine 
• 190059-40-6 [(S)-1-Benzyl-2-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of α-Amino acid derivatives via an electrophilic amination of chiral amide cuprates with Li t-Butyl-N-tosyloxycarbamate

The utility of lithium t-butyl-N-tosyloxycarbamate (LiBTOC) as a (+)NHBOC synthon in highly diastereoselective reactions with chiral cis-aminoindanol derived amide cuprates is described. The diastereoselectivities of these reactions ranged from 96% to greater than 99%. The subsequent transformation of these adducts to α-amino acids is also described.

Hydrogenation of BF2 complexes with 1,3-dicarbonyl ligands

The catalytic hydrogenation (H2, Pd/C) of a set of BF2 complexes with a 1,3-dicarbonyl structural unit leading to monocarbonyl compounds has been studied. The transformation presented is general for the aryl-substituted derivatives and occurs under mild conditions (H2, 1 bar, 25 °C) in methanol or THF.