142492-01-1 Usage
General Description
N-Methyl-N-methoxydifluoroacetamide, also known as MADFA, is a chemical compound with the molecular formula C5H8F2NO2. It is an organic compound that is commonly used as a reagent in organic synthesis and as a derivatization agent for the analysis of various compounds, especially in chromatography and mass spectrometry. MADFA is a colorless liquid with a boiling point of 122-123°C and is soluble in a variety of organic solvents. It is known for its unique chemical properties, including its ability to act as a strong hydrogen bond acceptor and its high thermal stability. Additionally, MADFA is an important building block for the synthesis of various pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 142492-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,4,9 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 142492-01:
(8*1)+(7*4)+(6*2)+(5*4)+(4*9)+(3*2)+(2*0)+(1*1)=111
111 % 10 = 1
So 142492-01-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H7F2NO2/c1-7(9-2)4(8)3(5)6/h3H,1-2H3
142492-01-1Relevant articles and documents
Photoredox Generation of Carbon-Centered Radicals Enables the Construction of 1,1-Difluoroalkene Carbonyl Mimics
Lang, Simon B.,Wiles, Rebecca J.,Kelly, Christopher B.,Molander, Gary A.
, p. 15073 - 15077 (2017)
Described is a facile, scalable route to access functional-group-rich gem-difluoroalkenes. Using visible-light-activated catalysts in conjunction with an arsenal of carbon-radical precursors, an array of trifluoromethyl-substituted alkenes undergoes radical defluorinative alkylation. Nonstabilized primary, secondary, and tertiary radicals can be used to install functional groups in a convergent manner, which would otherwise be challenging by two-electron pathways. The process readily extends to other perfluoroalkyl-substituted alkenes. In addition, we report the development of an organotrifluoroborate reagent to expedite the synthesis of the requisite trifluoromethyl-substituted alkene starting materials.
