1425253-99-1Relevant articles and documents
Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine-bridged nitric oxide synthase inhibitor with enhanced lipophilicity
Zefirova, Olga N.,Plotnikova, Evgeniya D.,Nurieva, Evgeniya V.,Peregud, Danil I.,Onufriev, Mikhail V.,Gulyaeva, Natalia V.
, p. 76 - 77 (2013)
2-Thia-4-azabicyclo[3.3.1]non-3-en-3-amine was synthesized as a lipophilic analogue of NO-synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine and found to be a potent inhibitor of inducible NO-synthase in vitro. The crystal structure of the key intermediate 2-thia-4-azabicyclo[3.3.1]nonane-3-thione (obtained by cyclization of trans-3-bromocyclohexylamine with carbon disulfide) was determined by X-ray analysis.
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation
Avenoza, Alberto,Bernardes, Gon?alo J. L.,Busto, Jesús H.,Corzana, Francisco,Ferhati, Xhenti,García-Sanmartín, Josune,Garrido, Pablo,Guerreiro, Ana,Jiménez-Moreno, Ester,Martínez, Alfredo,Peregrina, Jesús M.,Salas-Cubero, Marina
supporting information, p. 8580 - 8584 (2021/11/17)
A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media. Modulation of the amine pKa promo
An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow
Ballerini, Eleonora,Maggi, Raimondo,Pizzo, Ferdinando,Piermatti, Oriana,Gelman, Dmitri,Vaccaro, Luigi
, p. 474 - 479 (2016/03/04)
We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. Th
