1425411-54-6Relevant articles and documents
Targeting matrix metalloproteinases: Design of a bifunctional inhibitor for presentation by tumour-associated galectins
Bartoloni, Marco,Domínguez, Blanca E.,Dragoni, Elisa,Richichi, Barbara,Fragai, Marco,André, Sabine,Gabius, Hans-Joachim,Ardá, Ana,Luchinat, Claudio,Jiménez-Barbero, Jesús,Nativi, Cristina
supporting information, p. 1896 - 1902 (2013/03/28)
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time. Copyright