1425471-79-9

Upstream product

• 1425471-76-6 p-iodophenyl (3-O-allyl-2-O-benzoyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1→3)-(4-O-benzyl-2-O-methyl)-α-L-rhamnopyranoside 
• 1425471-68-6 phenyl 2-O-benzoyl-3-O-allyl-4-O-benzyl-1-thio-α-L-rhamnopyranoside 
• 1425471-65-3 phenyl 3-O-allyl-4-O-benzyl-1-thio-α-L-rhamnopyranoside 
• 1425471-60-8 p-iodophenyl 2-O-methyl-4-O-benzyl-α-L-rhamnopyranoside 
• 1425471-54-0 p-iodophenyl 3-O-allyl-4-O-benzyl-α-L-rhamnopyranoside 
• 1425471-51-7 p-iodophenyl 4-O-benzyl-α-L-rhamnopyranoside 
• 1425471-48-2 p-iodophenyl 2,3-O-isopropylidene-4-O-benzyl-α-L-rhamnopyranoside 
• 73-34-7 L-rhamnose 
• 1425471-42-6 p-iodophenyl 2,3,4-tri-O-acetyl-α-L-rhamnopyranoside 
• 7404-35-5 1,2,3,4-tetra-O-acetyl-L-rhamnopyranose 

Downstream Products

• 1425471-82-4 (2-O-benzyl-3-O-allyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1→3)-p-iodophenyl 2-O-methyl-4-O-benzyl-α-L-rhamnopyranoside 
• 1425471-85-7 (2,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1→3)-p-iodophenyl 2-O-methyl-4-O-benzyl-α-L-rhamnopyranoside 
• 1425471-88-0 p-iodophenyl (3,4-di-O-acetyl-2-O-methyl-α-L-fucopyranosyl)-(1→3)-(2,4-di-O-benzyl-α-L-rhamnopyranosyl)-(1→3)-(4-O-benzyl-2-O-methyl)-α-L-rhamnopyranoside 
• 1425471-91-5 C₄₇H₅₇IO₁₃ 

Relevant academic research and scientific papers

Synthesis and immunogenicity of PG-tb1 monovalent glycoconjugate

A PG-tb1 hapten from the West Beijing strains of Mycobacterium tuberculosis cell wall has been efficiently synthesized and conjugated to CRM197 in a simple way as linker-equipped carbohydrate by applying squaric acid chemistry for an original neoglycoprotein, creating a potent T-dependent conjugate vaccine. The intermediate monoester can be easily purified and the degree of incorporation can be monitored by MALDI-TOF mass spectrometry. After administered systemically in mice without any adjuvant, the conjugate induced high antigen-specific IgG levels in serum. Furthermore, following the third immunization, significant antibody titers frequently exceeding 0.8 million were observed in the sera of mice vaccinated with PG–CRM197 conjugate which showed the potential for preparation of TB vaccine.

Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from mycobacterium tuberculosis

Complex: The synthesis of the glycolipid PGL-tb1 present in the outer membrane of hypervirulent strains of Mycobacterium tuberculosis has been accomplished for the first time by using a highly convergent strategy featuring a Sonogashira coupling to unite a phenolic trisaccharide with the phthiocerol. Efficient asymmetric Cu-catalyzed 1,4-additions to unsaturated thioesters and cyclic enones have been employed to introduce the methyl groups. Copyright