1425495-89-1

Basic information

• Product Name: 3'-N-(1-oxyl-2,2,6,6-tetramethyl-4-tetrahydropyridinylcarbonyl)-amido-AVE8063
• Synonyms: 3'-N-(1-oxyl-2,2,6,6-tetramethyl-4-tetrahydropyridinylcarbonyl)-amido-AVE8063
• CAS NO: 1425495-89-1
• Molecular Weight: 495.596
• Mol File: 1425495-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3'-N-(1-oxyl-2,2,6,6-tetramethyl-4-tetrahydropyridinylcarbonyl)-amido-AVE8063(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-N-(1-oxyl-2,2,6,6-tetramethyl-4-tetrahydropyridinylcarbonyl)-amido-AVE8063(1425495-89-1)
• EPA Substance Registry System: 3'-N-(1-oxyl-2,2,6,6-tetramethyl-4-tetrahydropyridinylcarbonyl)-amido-AVE8063(1425495-89-1)

Safety Data

• Hazardous Substances Data: 1425495-89-1(Hazardous Substances Data)

Upstream product

• 31680-08-7 4-methoxy-3-nitrobenzaldehyde 
• 212262-55-0 (E)-3-(3'-nitro-4'-dimethoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)acrylic acid 
• 162705-13-7 (Z)-1-(4''-methoxy-3''-nitrophenyl)-2-(3',4',5'-trimethoxyphenyl)ethene 
• 38632-29-0 1-Oxyl-1,2,5,6-tetrahydro-2,2,6,6-tetramethylpyridin-4-carboxylic acid radical 
• 162705-07-9 3-amino-deoxycombretastatin A₄ 

Relevant articles and documents

Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents

Two series (14a-d and 21a-h) of novel spin-labeled combretastatin derivatives were synthesized and evaluated for cytotoxicity against four tumor cell lines (K562, SGC-7901, Hela and HepG-2). Simultaneously, a representative compound 21a was selected to investigate the antitumor mechanisms of these synthetic compounds. The results indicated that some of the compounds showed significant cytotoxicity against four tumor cell lines in vitro and were more active than etoposide, a clinically available anticancer drug. Among the newly synthesized compounds, 21a, 21b and 21c displayed the greatest cytotoxicity against three tested tumor cell lines (HEPG-2, BGC-832 and Hela), with IC 50 values ranging from 0.15 to 1.05 μM, compared with values of 0.014-0.403 μM for 3-amino-deoxycombretastatin A-4 (3). In addition, the mechanistic analysis revealed that compound 21a effectively interfered with tubulin dynamics to prevent mitosis in cancer cells, leading to cell cycle arrest and, eventually, dose dependent apoptosis.