142592-73-2Relevant academic research and scientific papers
Intramolecular thermal stepwise [2 + 2] cycloadditions: Investigation of a stereoselective synthesis of [n.2.0]-bicyclolactones
Throup, Adam,Patterson, Laurence H.,Sheldrake, Helen M.
supporting information, p. 9554 - 9559 (2016/10/22)
Fused cyclobutanes are found in a range of natural products and formation of these motifs in a straightforward and easy manner represents an interesting synthetic challenge. To this end we investigated an intramolecular variant of the thermal enamine [2 + 2] cyclisation, developing a diastereoselective intramolecular enamine [2 + 2] cyclisation furnishing δ lactone and lactam fused cyclobutenes in good yield and excellent diastereoselectivity.
Total synthesis of the ionophore antibiotic CP-61,405 (routiennocin)
Diez-Martin, David,Kotecha, Nikesh R.,Ley, Steven V.,Mantegani, Sergio,Menendez, J. Carlos,Organ, Helen M.,White, Andrew D.,Banks, Bernard J.
, p. 7899 - 7938 (2007/10/02)
The total synthesis of the spiroketal ionophore antibiotic routiennocin 1 (CP-61,405) employing π-allyltricarbonyl iron lactone complexes is described. These complexes were used as precursors for the preparation of substituted 2-phenylsulphonyl pyrans whi
