1426082-76-9Relevant academic research and scientific papers
Nickel-catalyzed decarboxylative acylation of heteroarenes by sp 2 C-H functionalization
Yang, Ke,Zhang, Cheng,Wang, Peng,Zhang, Yan,Ge, Haibo
, p. 7241 - 7244 (2014/06/23)
Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, thro
Organocatalytic C-H bond arylation of aldehydes to bis-heteroaryl ketones
Toh, Qiao Yan,McNally, Andrew,Vera, Silvia,Erdmann, Nico,Gaunt, Matthew J.
supporting information, p. 3772 - 3775 (2013/04/24)
An organocatalytic aldehyde C-H bond arylation process for the synthesis of complex heteroaryl ketones has been developed. By exploiting the inherent electrophilicity of diaryliodonium salts, we have found that a commercial N-heterocyclic carbene catalyst promotes the union of heteroaryl aldehydes and these heteroaromatic electrophile equivalents in good yields. This straightforward catalytic protocol offers access to ketones bearing a diverse array of arene and heteroarene substituents that can subsequently be converted into molecules displaying structural motifs commonly found in medicinal agents.
