1426097-02-0

Basic information

• Product Name: C₂₅H₁₈Cl₂N₆O₅S
• CAS NO: 1426097-02-0
• Molecular Weight: 585.427
• Mol File: 1426097-02-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₁₈Cl₂N₆O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₁₈Cl₂N₆O₅S(1426097-02-0)
• EPA Substance Registry System: C₂₅H₁₈Cl₂N₆O₅S(1426097-02-0)

Safety Data

• Hazardous Substances Data: 1426097-02-0(Hazardous Substances Data)

Upstream product

• 499-78-5 comenic acid 

Relevant articles and documents

Vectorization efforts to increase Gram-negative intracellular drug concentration: A case study on HldE-K inhibitors

In this paper, we present different strategies to vectorize HldE kinase inhibitors with the goal to improve their Gram-negative intracellular concentration. Syntheses and biological effects of siderophoric, aminoglycosidic, amphoteric, and polycationic vectors are discussed. While siderophoric and amphoteric vectorization efforts proved to be disappointing in this series, aminoglycosidic and polycationic vectors were able for the first time to achieve synergistic effects of our inhibitors with erythromycin. Although these effects proved to be nonspecific, this study provides information about the required stereoelectronic arrangement of the polycationic amines and their basicity requirements to fulfill outer membrane destabilization resulting in better erythromycin synergies.