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499-78-5

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  • Comenic Acid (5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid;2-Carboxy-5-hydroxy-4-pyrone; 5-Hydroxy-4-pyrone-2-carboxylic Acid),cas: 499-78-5 from fandachem

    Cas No: 499-78-5

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499-78-5 Usage

Uses

Different sources of media describe the Uses of 499-78-5 differently. You can refer to the following data:
1. 5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid can be used in the regenerative anti-inflammatory composition
2. Building block for an intramolecular olefin-α-pyrone cycloaddition providing the colchicine ring skeleton.

Check Digit Verification of cas no

The CAS Registry Mumber 499-78-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 499-78:
(5*4)+(4*9)+(3*9)+(2*7)+(1*8)=105
105 % 10 = 5
So 499-78-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4O5/c7-3-1-5(6(9)10)11-2-4(3)8/h1-2,8H,(H,9,10)

499-78-5 Well-known Company Product Price

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  • Aldrich

  • (681970)  5-Hydroxy-4-oxo-4H-pyran-2-carboxylicacid  97%

  • 499-78-5

  • 681970-1G

  • 2,211.30CNY

  • Detail
  • Aldrich

  • (681970)  5-Hydroxy-4-oxo-4H-pyran-2-carboxylicacid  97%

  • 499-78-5

  • 681970-5G

  • 7,920.90CNY

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499-78-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-hydroxy-4-oxopyran-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2-Carboxy-5-hydroxy-4-pyrone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:499-78-5 SDS

499-78-5Relevant articles and documents

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates

Baran?oková, Michaela,Cruz, Cristina D.,Ila?, Janez,Kikelj, Danijel,Lamut, Andra?,Ma?i?, Lucija Peterlin,Skok, ?iga,Tammela, P?ivi,Toma?i?, Tihomir,Zega, Anamarija,Zidar, Nace

, (2020/01/08)

Bacterial DNA gyrase is an important target for the development of novel antibacterial drugs, which are urgently needed because of high level of antibiotic resistance worldwide. We designed and synthesized new 4,5,6,7-tetrahydrobenzo[d]thiazole-based DNA gyrase B inhibitors and their conjugates with siderophore mimics, which were introduced to increase the uptake of inhibitors into the bacterial cytoplasm. The most potent conjugate 34 had an IC50 of 58 nM against Escherichia coli DNA gyrase and displayed MIC of 14 μg/mL against E. coli ΔtolC strain. Only minor improvements in the antibacterial activities against wild-type E. coli in low-iron conditions were seen for DNA gyrase inhibitor – siderophore mimic conjugates.

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