1426164-53-5 Usage
Description
Bis-Mal-Lysine-PEG4-TFP ester is a synthetic compound characterized by its two malimide end groups, which can react with thiol groups within a pH range of 6.5 to 7.5 to form thiolester bonds. Bis-Mal-Lysine-PEG4-TFP ester also features a TFP ester that can react with primary amine groups and is less prone to hydrolysis compared to NHS ester. The presence of a hydrophilic PEG (polyethylene glycol) linker enhances the compound's water solubility in aqueous environments, making it a versatile molecule for various applications.
Uses
Used in Bioconjugation:
Bis-Mal-Lysine-PEG4-TFP ester is used as a bioconjugation agent for the selective and efficient coupling of biomolecules, such as proteins or peptides, through the formation of stable thiolester bonds. Its pH-dependent reactivity and resistance to hydrolysis make it an ideal candidate for bioconjugation processes in various research and industrial applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bis-Mal-Lysine-PEG4-TFP ester is used as a component in the design of drug delivery systems. Its ability to form stable bonds with biomolecules allows for the development of targeted drug delivery systems, which can improve the efficacy and reduce the side effects of therapeutic agents.
Used in Diagnostics:
Bis-Mal-Lysine-PEG4-TFP ester can be employed as a component in the development of diagnostic tools, such as imaging agents or biosensors. Its reactivity with thiol groups and primary amine groups enables the specific binding and detection of target molecules, contributing to the advancement of diagnostic technologies.
Used in Material Science:
In the field of material science, Bis-Mal-Lysine-PEG4-TFP ester can be utilized as a building block for the development of novel biocompatible materials. Its ability to form stable bonds with a variety of molecules allows for the creation of materials with tailored properties, such as enhanced stability, biocompatibility, or controlled release of active agents.
Overall, Bis-Mal-Lysine-PEG4-TFP ester is a versatile compound with a wide range of applications in various industries, including bioconjugation, drug delivery, diagnostics, and material science, due to its unique chemical properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1426164-53-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,6,1,6 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1426164-53:
(9*1)+(8*4)+(7*2)+(6*6)+(5*1)+(4*6)+(3*4)+(2*5)+(1*3)=145
145 % 10 = 5
So 1426164-53-5 is a valid CAS Registry Number.
1426164-53-5Relevant articles and documents
Branched Discreet PEG Constructs
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, (2013/03/26)
Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.
