142617-98-9 Usage
General Description
1-(4-Fluoro-benzyl)-2-piperazin-1-yl-1H-benzimidazole is a chemical compound with a complex structure that includes a benzimidazole ring and a piperazine moiety. It is a benzimidazole derivative with a fluoro-substituted benzyl group and a piperazine side chain. 1-(4-FLUORO-BENZYL)-2-PIPERAZIN-1-YL-1H-BENZOIMIDAZOLE has potential pharmaceutical and therapeutic applications due to its ability to modulate various biological processes. It may exhibit pharmacological effects in the central nervous system, potentially affecting neurotransmitter receptors or other neurological targets. Further research into its biological activity and pharmacological potential is necessary to fully understand its properties and potential uses in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 142617-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,1 and 7 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 142617-98:
(8*1)+(7*4)+(6*2)+(5*6)+(4*1)+(3*7)+(2*9)+(1*8)=129
129 % 10 = 9
So 142617-98-9 is a valid CAS Registry Number.
142617-98-9Relevant articles and documents
Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds
Tian, Junjun,Vandermosten, Leen,Peigneur, Steve,Moreels, Lien,Rozenski, Jef,Tytgat, Jan,Herdewijn, Piet,Van den Steen, Philippe E.,De Jonghe, Steven
, p. 6332 - 6344 (2017/10/23)
Astemizole is a H1-antagonist endowed with antimalarial activity, but has hERG liabilities. Systematic structural modifications of astemizole led to the discovery of analogues that display very potent activity as inhibitors of the growth of the Plasmodium parasite, but show a decreased hERG inhibition, when compared to astemizole. These compounds can be used as starting point for the development of a new class of antimalarials.
