1426257-47-7Relevant academic research and scientific papers
Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide-alkyne click reaction in solution? A case study
Hohloch, Stephan,Sarkar, Biprajit,Nauton, Lionel,Cisnetti, Federico,Gautier, Arnaud
, p. 1808 - 1812 (2013)
Copper(I)-catalyzed azide alkyne cycloaddition is now a widely used tool for the synthesis of elaborated compounds. Until now, few stable and efficient copper(I) catalysts are available despite the limitations inherent to approaches employing the in situ reduction of a CuII species to deliver the catalytic system. We report that the combination of a copper(I)-mesoionic N-heterocyclic carbene (MIC) with a phenanthroline derivative generates a highly active catalyst, functioning in aqueous alcoholic solvent, without the intervention of a reducing agent. This catalytic system surpasses related 'normal' N-heterocyclic carbene-based systems in their efficiency.
