1426259-88-2Relevant articles and documents
Discovery and preliminary structure-activity relationship of arylpiperazines as novel, brain-penetrant antiprion compounds
Li, Zhe,Gever, Joel R.,Rao, Satish,Widjaja, Kartika,Prusiner, Stanley B.,Silber, B. Michael
, p. 397 - 401 (2013/06/27)
Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrP Sc) of a normall