1426318-08-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel, highly active soft rock inhibitors
Boland, Sandro,Bourin, Arnaud,Alen, Jo,Geraets, Jacques,Schroeders, Pieter,Castermans, Karolien,Kindt, Nele,Boumans, Nicki,Panitti, Laura,Fransen, Silke,Vanormelingen, Jessica,Stassen, Jean Marie,Leysen, Dirk,Defert, Olivier
, p. 4309 - 4324 (2015/06/08)
ROCK1 and ROCK2 play important roles in numerous cellular functions, including smooth muscle cell contraction, cell proliferation, adhesion, and migration. Consequently, ROCK inhibitors are of interest for treating multiple indications including cardiovas
NOVEL SOFT ROCK INHIBITORS
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Page/Page column 32; 33, (2013/03/28)
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases and ophthalmic diseases.
