1426329-85-2

Upstream product

• 1426329-84-1 benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate 
• 1426329-83-0 benzyl 3,4-bis(4-isopropoxyphenyl)-1H-pyrrole-2-carboxylate 
• 1426329-82-9 benzyl N-benzenesulfonyl-3,4-bis(4-isopropoxyphenyl)pyrrole-2-carboxylate 
• 1426329-80-7 benzyl N-benzenesulfonyl-3,4-dibromopyrrole-2-carboxylate 

Downstream Products

• 1426329-86-3 7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one 
• 1426329-87-4 7,8-bis(4-hydroxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one 

Relevant academic research and scientific papers

Total synthesis of the marine natural products lukianols A and B

Total synthesis of the pyrrolic marine natural products lukianols A (1) and B (2) has been achieved using N-benzenesulfonyl-3,4-dibromopyrrole (3) as a common starting material. The key synthetic strategy developed is the combined bromine-directed lithiation and palladium-catalyzed cross-coupling of 3 to produce 3,4-diarylpyrrol-2-carboxylates. Regioselective iodination of the phenolic intermediate 24 was thoroughly investigated for the synthesis of lukianol B.