3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

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Chemical Name:3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid
CAS No.:1426329-85-2
Molecular Formula:C₃₂H₃₃NO₆
Molecular Weight:527.617
Hs Code.:

Synonyms:3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

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Chemical Property of 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

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Technology Process of 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

There total 4 articles about 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1426329-84-1
benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

: 1426329-85-2
3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: With palladium on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-80-7
benzyl N-benzenesulfonyl-3,4-dibromopyrrole-2-carboxylate

: 1426329-85-2
3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 1,1'-bis(di-tertbutylphosphino)ferrocene; sodium carbonate / tetrahydrofuran; water / 14 h / Reflux; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

4: palladium on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

With 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-82-9
benzyl N-benzenesulfonyl-3,4-bis(4-isopropoxyphenyl)pyrrole-2-carboxylate

: 1426329-85-2
3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3: palladium on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

With palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077