1426338-81-9Relevant articles and documents
Grignard-mediated reduction of 2,2,2-trichloro-1-arylethanones
Essa, Ali H.,Lerrick, Reinner I.,?ift?i, E?e,Harrington, Ross W.,Waddell, Paul G.,Clegg, William,Hall, Michael J.
, p. 5793 - 5803 (2015/05/27)
2,2,2-Trichloro-1-aryl-ethanones can be reduced by RMgX to the corresponding 2,2-dichloro-1-arylethen-1-olates and trapped with a range of electrophiles resulting in either reduction, reduction/aldol, reduction/Claisen condensation or reduction/aldol-Tishchenko products. In addition we demonstrate that 2,2-dichloro-1-arylethen-1-olates undergo counter-ion controlled Darzens condensations, which can be followed by a thermal rearrangement as a route to 1,3-diaryl-3-chloropropane-1,2-diones.
