1426338-85-3Relevant academic research and scientific papers
Reduction of 2,2,2-trichloro-1-arylethanones by RMgX: Mechanistic investigation and the synthesis of substituted α,α-dichloroketones
Essa, Ali H.,Lerrick, Reinner I.,Tuna, Floriana,Harrington, Ross W.,Clegg, William,Hall, Michael J.
supporting information, p. 2756 - 2758 (2013/04/23)
2,2,2-Trichloro-1-arylethanones undergo high yielding reductions to the corresponding 2,2-dichloro-1-arylethanones in the presence of RMgX. A single electron transfer mechanism for the reaction is proposed based on trapping experiments. Reaction of the intermediate enolates with a range of electrophiles is described, providing a convenient route to substituted α,α- dichloro-β-hydroxyketones and related molecules. The Royal Society of Chemistry 2013.
