1426396-72-6

Basic information

• Product Name: 5-chloro-2-hydroxy-N-(4-methoxy-3,5-bis-trifluoromethyl-phenyl)-benzamide
• Synonyms: 5-chloro-2-hydroxy-N-(4-methoxy-3,5-bis-trifluoromethyl-phenyl)-benzamide
• CAS NO: 1426396-72-6
• Molecular Weight: 413.704
• Mol File: 1426396-72-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-hydroxy-N-(4-methoxy-3,5-bis-trifluoromethyl-phenyl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-hydroxy-N-(4-methoxy-3,5-bis-trifluoromethyl-phenyl)-benzamide(1426396-72-6)
• EPA Substance Registry System: 5-chloro-2-hydroxy-N-(4-methoxy-3,5-bis-trifluoromethyl-phenyl)-benzamide(1426396-72-6)

Safety Data

• Hazardous Substances Data: 1426396-72-6(Hazardous Substances Data)

Upstream product

• 1430814-38-2 C₉H₅F₆NO₃ 
• 1365643-24-8 2-bromo-5-nitro-1,3-bis(trifluoromethyl)benzene 
• 268733-18-2 4-bromo-3,5-bis(trifluoromethyl)benzenamine 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 1426396-69-1 C₉H₇F₆NO 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 

Relevant articles and documents

2-HYDROXYARYLAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.