1426434-49-2

Upstream product

• 1426434-43-6 (9R,11S)-methyl 7-(tert-butoxycarbonyl)-9-(3,4-dimethoxyphenyl)-12-methyl-3,8-dioxo-1-phenyl-2,4-dioxa-7,10-diazatridecane-11-carboxylate 
• 1426434-42-5 (9R,11S)-methyl 9-(3,4-dimethoxyphenyl)-11-isopropyl-3,8-dioxo-1-phenyl-2,4-dioxa-7,10-diazadodecan-12-oate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 1426434-52-7 C₂₂H₃₉NO₄Si 
• 1426434-48-1 (S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol 
• 72-18-4 L-valine 
• 1426434-47-0 (S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate 
• 1426434-44-7 (S)-methyl 2-((R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethylamino)-3-methylbutanoate 

Downstream Products

• 1426434-53-8 diborane 

Relevant academic research and scientific papers

An approach to the synthesis of enantiopure tetrahydroisoquinoline via a key asymmetric Ugi reaction

An approach to the synthesis of the multisubstituted tetrahydroisoquinoline featuring an asymmetric Ugi reaction of α-amino acid, aromatic aldehyde and an isocyanide has been developed. The promising utility of the strategy is demonstrated by a synthesis of an enantiopure functionalized 1,3-trans-tetrahydroisoquinolin-4-ol from natural l-valine. The configuration of the two stereocenters at C-1 and C-4, generated in the Ugi reaction and Pomeranz-Fritsch-type cyclization separately, was controlled very well and determined by NMR studies. Georg Thieme Verlag Stuttgart New York.