1426436-48-7

Basic information

• Product Name: C₂₇H₃₀ClN₃O₄
• Synonyms: C₂₇H₃₀ClN₃O₄
• CAS NO: 1426436-48-7
• Molecular Weight: 496.006
• Mol File: 1426436-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₀ClN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₀ClN₃O₄(1426436-48-7)
• EPA Substance Registry System: C₂₇H₃₀ClN₃O₄(1426436-48-7)

Safety Data

• Hazardous Substances Data: 1426436-48-7(Hazardous Substances Data)

Upstream product

• 481-06-1 santonin 
• 480438-57-1 3-chloro-4-propoxylphenylboronic acid 
• 1426436-21-6 C₁₈H₂₀O₃ 
• 14794-71-9 (-)-α-desmotroposantonin acetate 
• 13743-88-9 (-)-α-desmotroposantonin 

Relevant articles and documents

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: A report

α-Santonin derived new series of 1,2,3-triazoles synthesized through Azide-Alkyne Huisgen 1,3-dipolar cycloaddition reaction between substituted aryl azide and a propargylated α-desmotrosantonin were bio-evaluated for their diminutive effect on ConA induced T-cell and LPS induced B-cell proliferation. Interestingly, most of the synthesized compounds showed better immunosuppressant activity than α-santonin. Triazole derivatives 9, 10, 17, 18, 29, and 30 displayed significant diminutive effect on cell proliferation. Compounds 12 and 13 were found selective against ConA T-cell proliferation exhibiting >90% inhibition at 1 × 10-6 M concentration. The present study resulted in identification of several triazole derivatives as effective immunosuppressive agents.