142644-39-1 Usage
General Description
N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate is a nucleoside analog and a derivative of the antiretroviral medication zidovudine (AZT). It is commonly used in the treatment of HIV and AIDS. N(3)-methyl-3'-azido-3'-deoxythymidine 5'-triphosphate is a triphosphate, meaning it contains three phosphate groups, and is essential for its activity as an antiviral agent. It works by inhibiting the reverse transcriptase enzyme, which is necessary for the replication of HIV. By mimicking the structure of thymidine, it is able to interfere with the viral DNA synthesis and block the virus from multiplying. The addition of the azido group increases the potency of the compound by enhancing its affinity for the viral DNA polymerase, making it an effective weapon against HIV replication.
Check Digit Verification of cas no
The CAS Registry Mumber 142644-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,4 and 4 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 142644-39:
(8*1)+(7*4)+(6*2)+(5*6)+(4*4)+(3*4)+(2*3)+(1*9)=121
121 % 10 = 1
So 142644-39-1 is a valid CAS Registry Number.
142644-39-1Relevant articles and documents
Synthesis and anti-human immunodeficiency virus type 1 (HIV-1) activity of 3-substituted derivatives of 3'-azido-3'-deoxythymidine (AZT), and inhibition of HIV-1 reverse transcriptase by their 5'-triphosphates
Kitade,Suzuki,Hirota,Maki,Nakane,Ono,Baba,Shigeta
, p. 920 - 924 (1992)
Various 3-substituted 3'-azido-3'-deoxythymidine analogs (2a-i) were prepared by the reaction of 3'azido-3'-deoxythymidine (1), AZT with N,N-dimethylformamide dialkylacetal or alkyl bromide in the presence of base and their activities against human-immuno
