142644-48-2Relevant academic research and scientific papers
Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs
Adams, David R.,Perez, Caroline,Maillard, Michel,Florent, Jean-Claude,Evers, Michel,Hénin, Yvette,Litvak, Simon,Litvak, Laura,Monneret, Claude,Grierson, David S.
, p. 1550 - 1558 (1997)
A series of 22 derivatives of AZT substituted at the N-3 position of the thymine base were prepared and evaluated for anti-HIV activity in cell culture (Lai strain of HIV-1 in CEM-c113 cells). The AZT analogs bearing a N- 3 amino group (7), a hydroxyalkyl
Synthesis and anti-human immunodeficiency virus type 1 (HIV-1) activity of 3-substituted derivatives of 3'-azido-3'-deoxythymidine (AZT), and inhibition of HIV-1 reverse transcriptase by their 5'-triphosphates
Kitade,Suzuki,Hirota,Maki,Nakane,Ono,Baba,Shigeta
, p. 920 - 924 (2007/10/02)
Various 3-substituted 3'-azido-3'-deoxythymidine analogs (2a-i) were prepared by the reaction of 3'azido-3'-deoxythymidine (1), AZT with N,N-dimethylformamide dialkylacetal or alkyl bromide in the presence of base and their activities against human-immuno
