142645-50-9

Usage

Uses

Used in Hematological Applications:
Folinic acid is utilized as a therapeutic agent for treating certain types of anemia, where it helps in the production of healthy red blood cells by providing the body with an easily assimilated form of folic acid.
Used in Oncological Applications:
In the field of oncology, folinic acid is employed in the treatment of specific types of cancer, such as colorectal cancer. It aids in mitigating the toxic effects of folate antagonists and can also be used to counteract the side effects of methotrexate, a medication frequently used in cancer treatment.
Used in Pharmaceutical Formulation:
Folinic acid is used as a key component in pharmaceutical formulations to prevent the side effects associated with methotrexate, ensuring safer and more effective cancer treatment.
Used in Antidote Therapy:
Folinic acid serves as an antidote in cases where there is an overdose of folate antagonists, helping to counteract their toxic effects and restore normal folate levels in the body.

Upstream product

• 708-75-8 2-amino-6-methylpteridin-4(1H)-one 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 708-75-8 6-methylpterin 

Downstream Products

• 142645-52-1 2-(2,2-Dimethyl-propionylamino)-6-methyl-4-oxo-4,6,7,8-tetrahydro-3H-pteridine-5-carboxylic acid benzyl ester 
• 708-75-8 2-amino-6-methylpteridin-4(1H)-one 
• 708-74-7 2,4-diamino-6-methylpteridine 

Relevant academic research and scientific papers

The first microwave-assisted regiospecific synthesis of 6-substituted pterins

The pyrazine ring was developed in a pyrimidine and in a benzene by Isay type condensations under microwave irradiation to afford pterin and quinoxaline systems. Interestingly, the desired isomerically free 6-substituted pterins including pterin sugar derivatives were synthesised in moderate to good yields whereas mixtures of both 6- and 7-isomers (major) are generally obtained using conventional Isay type condensations.

PROTECTION AND DEPROTECTION OF FUSED 2-AMINO-4(3H)PYRIMIDONES: CONVERSION OF PTERINS AND 5-DEAZAPTERINS TO 2,4-DIAMINO DERIVATIVES

5-Deazapterins and pterins are readily converted to their 4-deoxy-4-amino derivatives (a lactam-to-amidine conversion) by reaction with 4-chlorophenyl phosphorodichloridate and 1,2,4-triazole to give intermediate 4- derivatives, followed by reaction with aqueous ammonia.Some anomalous results obtained by application of the Mitsunobu reaction (normally a lactam-to-lactim ether conversion) to 5-deazapterins are detailed.

Model Studies Related to the Cofactor of Oxomolybdoenzymes. Part 4. Reduction of the Pyrazine Ring in Quinoxalines and Pteridines

Reduction of quinoxalines and pteridines with sodium borohydride or sodium cyanoborohydride in the presence of benzyl chloroformate gives N-benzyloxycarbonyl- or N,N'-bisbenzyloxycarbonyl tetrahydro derivatives.