142650-77-9

Upstream product

• 121-43-7 Trimethyl borate 
• 104224-63-7 2-(1-adamantyl)-4-bromoanisole 
• 108-95-2 phenol 
• 768-95-6 1-adamanthanol 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 191934-12-0 methyl 2-[3-(1-adamantyl)-4-methoxyphenoxymethyl]-4-thiophenecarboxylate 
• 191933-78-5 O-3-(1-adamantyl)-4-methoxyphenyl dimethylthiocarbamate 

Relevant academic research and scientific papers

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4- bromophenol, A key intermediate of adapalene

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid.The sole byproduct of the adamantylation reaction,namely water,could be converted into the solvent acetic acid by addition of a slight excess of acetic anhydride during the work-up procedure,making the process waste-free except for regeneration of the ionexchange resin,and facilitating the recycling of the resin catalyst.The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least ten times without a significant loss of activity.The key intermediate of adapalene,2-(1-adamantyl)-4-bromophenol,could be produced by means of this waste-free process.

Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics

Di(aromatic) compounds corresponding to the following formula: STR1 in which: Ar represents either STR2 n=1 or 2 or: STR3 X represents a divalent radical, Z represents O, S or a divalent radical, and R1, R2, R3, R4 and R5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R1 is a carboxylic acid function. Use in human and veterinary medicine and in cosmetics.