1426535-37-6

Basic information

• Product Name: C₃₀H₃₅NO₈
• Synonyms: C₃₀H₃₅NO₈
• CAS NO: 1426535-37-6
• Molecular Weight: 537.61
• Mol File: 1426535-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₃₅NO₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₃₅NO₈(1426535-37-6)
• EPA Substance Registry System: C₃₀H₃₅NO₈(1426535-37-6)

Safety Data

• Hazardous Substances Data: 1426535-37-6(Hazardous Substances Data)

Upstream product

• 1426535-35-4 C₂₉H₃₃NO₈ 
• 50-24-8 prednisolon 
• 2001-32-3 3-(2-nitrophenyl)propionic acid 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 859197-37-8 dimethyl 2-(2-nitrobenzyl)-malonate 

Downstream Products

• 95825-22-2 C₃₀H₃₆O₆ 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 50-24-8 prednisolon 

Relevant articles and documents

A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib

Celecoxib is a COX-2 inhibitor drug that can be used to reduce the risk of colorectal adenocarcinoma. Glucocorticoids are used in the treatment of inflammatory bowel disease. A limitation to the use of both drug types is that they undergo absorption from the intestinal tract with serious side effects. The prodrug systems introduced here involve forming a nitro-substituted acylsulfonamide group in the case of celecoxib and a nitro-substituted 21-ester for the glucocorticoids. Drug release is triggered by the nitro reductase action of the colonic microflora, liberating a cyclization competent species. The release of the active parent drugs was evaluated in vitro using Clostridium perfringens and epithelial transport through Caco-2 monolayer evaluation was carried out to estimate the absorption properties of the prodrugs compared to the parental drugs.