2001-32-3

Basic information

• Product Name: 3-(2-nitrophenyl)propionic acid
• Synonyms: 3-(2-nitrophenyl)propionic acid;2-(2-Carboxyethyl)-1-nitrobenzene;2-Nitrobenzenepropanoic acid;3-(2-Nitrophenyl)propanoic acid;3-(2-Nitrophenyl)
• CAS NO: 2001-32-3
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17206
• EINECS: 217-889-8
• Mol File: 2001-32-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 331.83°C (rough estimate)
• Flash Point: 156.4 °C
• Appearance: /
• Density: 1.3544 (rough estimate)
• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.5(at 25℃)
• CAS DataBase Reference: 3-(2-nitrophenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-nitrophenyl)propionic acid(2001-32-3)
• EPA Substance Registry System: 3-(2-nitrophenyl)propionic acid(2001-32-3)

Safety Data

• Hazardous Substances Data: 2001-32-3(Hazardous Substances Data)

Usage

General Description

3-(2-nitrophenyl)propionic acid, also known as fenoprofen, is a nonsteroidal anti-inflammatory drug (NSAID) typically used to relieve pain and reduce inflammation in conditions such as arthritis. Its chemical structure consists of a propionic acid backbone with a 2-nitrophenyl group attached to the third carbon, giving it its analgesic and anti-inflammatory properties. Fenoprofen works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain and inflammation. It is typically administered orally and is metabolized by the liver before being excreted in the urine. However, it may also have potential side effects, such as gastrointestinal irritation, renal toxicity, and an increased risk of cardiovascular events. Overall, 3-(2-nitrophenyl)propionic acid is a commonly used medication for pain relief and inflammation, but its use should be carefully monitored due to its potential side effects.

InChI:InChI=1/C9H9NO4/c11-9(12)6-5-7-3-1-2-4-8(7)10(13)14/h1-4H,5-6H2,(H,11,12)

Upstream product

• 683215-25-0 (2-nitro-benzyl)-malonic acid 
• 612-23-7 2-nitrobenzyl chloride 
• 105-53-3 diethyl malonate 
• 7647-01-0 hydrogenchloride 
• 59803-35-9 (2-nitro-benzyl)-malonic acid diethyl ester 
• 2033-24-1 cycl-isopropylidene malonate 
• 552-89-6 2-nitro-benzaldehyde 
• 15121-84-3 2-nitro-benzeneethanol 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 114304-24-4 3-(2-nitrophenyl)propionitrile 
• 7697-37-2 nitric acid 
• 501-52-0 3-Phenylpropionic acid 
• 16793-89-8 (2-bromoethyl)-2-nitrobenzene 
• 151-50-8 potassium cyanide 

Downstream Products

• 1664-65-9 3-(2-nitrophenyl)propionic acid methyl ester 
• 18910-10-6 α-bromo-β-(2-nitrophenyl)propionic acid 
• 650629-19-9 5'-(3-(2-nitrophenyl)propionyl)-2'-deoxy-5-fluorouridine 
• 650629-24-6 5'-(3-(2-aminophenyl)propionyl)-2'-deoxy-5-fluorouridine 
• 70875-55-7 N-(3-quinolyl)-3-(2-nitrophenyl)propanamide 
• 154078-52-1 N-(4-methoxyphenyl)-3-(2-aminophenyl)propanamide 
• 154078-53-2 N-(3-quinolyl)-3-(2-aminophenyl)propanamide 
• 154078-39-4 N-(4-methoxyphenyl)-3-(2-nitrophenyl)propanamide 
• 1014977-73-1 N-(4-chlorobenzyl)-3-(2-nitrophenyl)propionamide 
• 1426535-45-6 C₂₆H₂₁F₃N₄O₅S 
• 1426535-37-6 C₃₀H₃₅NO₈ 

Relevant articles and documents

Design, synthesis and biological evaluation of a novel platinum(II) complex possessing bioreductive groups for cancer therapy

Cisplatin is one of the most successful antitumor agents, yet also restricted by its poor cellular uptake and low selectivity. Since 3-(2-nitrophenyl) propionic acid (NPPA) has been reported as a bioreductive prodrug moiety, herein we combined NPPA with cisplatin (compound 1) to improve its lipophilicity and targetability and then to improve the antitumor outcomes. In addition, compound 2 possessing 3-phenyl propionic acid (PPA) was also synthesized as a comparison to test the influence of the NPPA to the cytotoxicity, since PPA was not a bioreductive moiety. Bioevaluations showed that 1 displayed more potent antitumor potency than cisplatin and 2, suggesting Pt(II) complexes possessing NPPA groups may be a good strategy for future platinum drug discovery.

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

Synthesis of isomeric (3,3,3-trifluoropropyl)anilines

Ortho-, meta- and para-isomers of (3,3,3-trifluoropropyl)aniline have been prepared in 60-70 g amount from the corresponding nitrobenzaldehydes in three steps. The key synthesis step was a transformation of the carboxylic group of 3-(nitrophenyl)propanoic acids into the trifluoromethyl group by SF4.