142654-29-3

Upstream product

• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 98-83-9 isopropenylbenzene 
• 142654-28-2 O-benzyl-N,N’-di-tert-butoxycarbonylhydroxylamine 
• 7440-44-0 pyrographite 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 666706-29-2 (R)-α-N,N-diboc-aminoxy-γ-butyrolactone 
• 142654-28-2 O-benzyl-N,N’-di-tert-butoxycarbonylhydroxylamine 
• 1290118-61-4 N,N-di(tert-butoxycarbonyl)-O-[3-(4-iodo)phenyl]propylhydroxylamine 

Relevant academic research and scientific papers

MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

Rapid synthesis of alkoxyamine hydrochloride derivatives from alkyl bromide and N,N′-Di-tert-butoxycarbonylhydroxylamine [(Boc)2NOH]

The conventional route to alkoxyamine hydrochloride derivatives is by reaction of alkyl bromides with N-hydroxyphthalimide or N-hydroxysuccinimide followed by addition of hydrazine and HCl. Transformation of an alkyl bromide to the corresponding alkoxyamine hydrochloride can be accomplished more rapidly in good yields without using hazardous hydrazine by reaction of (Boc) 2NOH (N,N′-di-tert-butoxycarbonylhydroxylamine) and alkyl bromide followed by addition of HCl. Alkoxyamine hydrochlorides are powerful reagents in organic synthesis that can be used to synthesize alkoxyimino derivatives after condensation with a ketone or aldehyde. Copyright

Copper-catalyzed allylic hydroxyamination and amination of alkenes with Boc-hydroxylamine

Olefins react regioselectively with Boc-NHOH in the presence of Cu(I,II) salts to produce allyl-N(OH)(Boc) derivatives, apparently via the intermediacy of Boc-NO; yields and rates are dramatically improved by the addition of H 2O2. The corresponding allylamine derivatives, allyl-NH(Boc), are formed selectively from Boc-NHOH/olefin with CuBr/P(OEt) 3.

A METHOD OF PREPARING ENANTIOMERS OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES

The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.

HETEROARYL DERIVATIVES OF MONOCYCLIC BETA-LACTAM ANTIBIOTICS

Antibacterial activity is exhibited by novel compounds having the formula where R1, R2, and M are as defined herein and X is ?(CH2)n? wherein n is 0, 1, 2, 3 or 4 or CR3R4 wherein R3 and R4 are the same or different and each is hydrogen, ?CH3 or ?C2H5 or R3 and R4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring