1426682-83-8Relevant academic research and scientific papers
Asymmetric synthesis of tert-butyl ((1R,4aR,8R,8aR)-1-hydroxyoctahydro-1H-isochromen-8-yl)carbamate
Rubia, Alfonso G.,Salgado, Mateo M.,Nieto, Carlos T.,Manchado, Alejandro,Díez, David,Sanz, Francisca,Garrido, Narciso M.
, p. 1394 - 1400 (2017)
The asymmetric synthesis of methyl (E)-4-((1R,2S,3R)-3-amino-2-((E)-2-methoxycarbonyl-eten-1-yl)cyclohexyl)but-2-enoate 14 has been achieved from dimethyl (2E,7E)-nona-2,7-dienedioate 2. A key step is the asymmetric synthesis of 1-hydroxyoctahydro-1H-isochromene derivative 5 whose X-ray analysis corroborated the stereochemistry of the new stereocenters. The asymmetric synthesis of the isochromenyl acetate derivative 11 shows the potential of this methodology for fused cyclohexanic system heterocyclic synthesis.
Enantioselective synthesis of a (1 R,5 R,9 R)-2-azabicyclo[33.1]nonane-9- carboxylic acid with an embedded morphan motif: A multipurpose product
Garrido, Narciso M.,Nieto, Carlos T.,Díez, David
, p. 169 - 172 (2013/02/25)
A convenient asymmetric synthesis of (1R,5R,9R)-2-azabicyclo[3.3.1]nonane- 9-carboxylic acid is described, starting from (2E,7E)-dimethyl nonadienedioate. The route involves a stereoselective domino Michael-Dieckman process that furnishes a 1,2,3-trisubst
