1426688-71-2

Basic information

• Product Name: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one
• Synonyms: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one
• CAS NO: 1426688-71-2
• Molecular Weight: 376.433
• Mol File: 1426688-71-2.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one(1426688-71-2)
• EPA Substance Registry System: 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one(1426688-71-2)

Safety Data

• Hazardous Substances Data: 1426688-71-2(Hazardous Substances Data)

Upstream product

• 1426689-05-5 tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 205383-87-5 tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate 
• 1426688-88-1 C₂₇H₂₉FN₄O₃ 

Downstream Products

• 1426688-70-1 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one 
• 1426688-94-9 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-(pyrimidin-2-yl)spiro[indoline-3,3'-pyrrolidin]-2-one 
• 1426688-92-7 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-(methylsulfonyl)spiro[indoline-3,3'-pyrrolidin]-2-one 
• 1426688-89-2 1'-acetyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one 
• 1426688-78-9 1'-cyclopentyl-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one 
• 1426688-86-9 1'-(2,2-difluoroethyl)-1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one 

Relevant articles and documents

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

This Letter describes the further optimization of an MLPCN probe molecule (ML137) through the introduction of 5- and 6-membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M

SUBSTITUTED BENZYLSPIROINDOLIN-2-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1

In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.