142669-79-2Relevant academic research and scientific papers
Urea thiadiazole inhibitors of plasminogen activator inhibior-1
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Page/Page column 21, (2010/02/11)
Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
Pyridyl derivatives and pharmaceutical compositions comprising these compounds
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, (2008/06/13)
This invention relates to pyridyl derivatives of the formula STR1 wherein X, Y, A, n and R3 to R8 are defined hereinbelow, the enantiomers thereof, the cis- and trans-isomers thereof, which have antithrombotic pharmaceutical activity
6,6-Disubstituted hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors
Soyka,Heckel,Nickl,Eisert,Muller,Weisenberger
, p. 26 - 39 (2007/10/02)
A series of ω-disubstituted alkenoic acid derivatives were designed and synthesized as antithrombotic inhibitors of thromboxane A2 synthetase and thromboxane A2 receptor antagonists. Hexenoic acid derivatives with a 3- pyridyl group
