1426855-22-2Relevant academic research and scientific papers
Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
Fraser, Benjamin H.,Hamilton, Stephanie,Krause-Heuer, Anwen M.,Wright, Philip J.,Greguric, Ivan,Tucker, Simon P.,Draffan, Alistair G.,Fokin, Valery V.,Sharpless, K. Barry
, p. 383 - 386 (2013/06/04)
The copper catalyzed azide alkyne cycloaddition (CuAAC) reaction-the quintessential 'click' reaction-was used to synthesise dimers of the neuraminidase inhibitor zanamivir in high yields. The effect upon anti-viral activity of varying the linker length and the number of triazole units was explored. All dimers were tested for anti-viral activity against influenza A/Sydney/5/97 and B/Harbin/7/94 in a cytopathic effect (CPE) assay. The Royal Society of Chemistry.
