1426899-75-3

Upstream product

• 4079-51-0 1-(3-bromophenyl)-2-hydroxyethan-1-one 
• 1426899-74-2 (E)-1-(5-bromo-2-hydroxy-phenyl)-3-o-tolyl-propenone 
• 1450-75-5 5-Bromo-2-hydroxyacetophenone 

Downstream Products

• 1426899-76-4 6-bromo-2-o-tolyl-chroman-4-ol 
• 1426900-45-9 2-(2-o-tolyl-chroman-6-yloxy)thiazole-5-carboxylic acid 
• 1426899-84-4 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid methyl ester 
• 1426899-70-8 phosphoric acid mono-(2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]amino}ethyl) ester 
• 1426899-80-0 2-o-tolyl-chroman-6-ol 
• 1426899-88-8 phosphoric acid dibenzyl ester 2-{[2-((S)-2-o-tolyl-chroman-6-yloxy)-thiazole-5-carbonyl]-amino}-ethyl ester 
• 1426899-86-6 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid (2-hydroxy-ethyl)-amide 
• 1426899-85-5 2-(2-o-tolyl-chroman-6-yloxy)-thiazole-5-carboxylic acid lithium salt 

Relevant academic research and scientific papers

Substituted 2 - (chroman - 6 - yloxy) thiazole and use thereof as a medicament

The invention relates to a substitutional-2-(chroman-6-oxyl) thiazole shown as a formula I, wherein Ar, R2, R3 and R4 are defined in claims. The compound shown as the formula I is a sodium-calcium permutoid (NCX) inhibitor, especially a sodium-calcium permutoid subtype 1 (NCX1) inhibitor, and is applicable to treatment of various disorders caused by calcium unbalance in cells, such as arrhythmia, cardiac failure and apoplexy. The invention also relates to a method for preparing the compound shown as the formula I, an application of the compound as the medicine and a medicine composition containing the compound.

Substd. 2 - (chromane-6-carbonoyloxysilane) and its use as medicine iminothiazole-

PROBLEM TO BE SOLVED: To provide: a compound usable for disorders such as arrhythmia, cardiac failure and cerebral apoplexy caused by disturbance of intracellular calcium homeostasis of sodium-calcium exchanger (NCX), especially sodium-calcium exchanger of subtype 1 (NCX1); production method of the compound; use thereof as a pharmaceutical; and a pharmaceutical composition including the compound.SOLUTION: There is disclosed a substituted 2-(chroman-6-yloxy)-thiazole compound expressed by general formula I.

SUBSTITUTED CHROMAN-6-YLOXY-CYCLOALKANES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1 ), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula (I), in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.