1426901-75-8Relevant academic research and scientific papers
Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes
Dubrovskiy, Anton V.,Jain, Prashi,Shi, Feng,Lushington, Gerald H.,Santini, Conrad,Porubsky, Patrick,Larock, Richard C.
supporting information, p. 193 - 201 (2013/05/23)
A library of benzisoxazoles has been synthesized by the [3 + 2] cycloaddition of nitrile oxides with arynes and further diversified by acylation/sulfonylation and palladium-catalyzed coupling processes. The eight key intermediate benzisoxazoles have been prepared by the reaction of o-(trimethylsilyl)aryl triflates and chlorooximes in the presence of CsF in good to excellent yields under mild reaction conditions. These building blocks have been used as the key components of a diverse set of 3,5,6-trisubstituted benzisoxazoles.
