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Usage

Uses

Used in Pharmaceutical Industry:
2,5-DIBROMOBENZENESULFONYL CHLORIDE is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. It plays a crucial role in the synthesis of 1,1-dimethylethyl (2S,4R)-4-[(2,5-dibromophenyl)sulfonyl]amino-2-methyl-1-pyrrolidinecarboxylate and 1-benzyl-2-(2,5-dibromophenyl)indole, which have potential applications in drug development.
Used in Chemical Industry:
In the chemical industry, 2,5-DIBROMOBENZENESULFONYL CHLORIDE is used as a reagent for the preparation of various organic compounds, including:
Methyl (2E)-3-[2-octyl-3-(2-methoxy-2-oxoethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-6-yl]acrylate
Methyl (2E)-3-[2-(4-methoxyphenyl)-3-(2-methoxy-2-oxoethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-6-yl]acrylate
Ethyl (2E)-3-[3-(2-ethoxy-2-oxoethyl)-2-(2-methoxybenzyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-6-yl]acrylate
These compounds have potential applications in various chemical processes and can be used as intermediates for the synthesis of other organic compounds.

InChI:InChI=1/C6H3Br2ClO2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 861529-74-0 2,5-dibromo-benzenesulfonic acid-anhydride 

Downstream Products

• 4358-74-1 1-Propyl-<2.5-dibrombenzol>-sulfonat 
• 4358-71-8 1-Pentyl-<2.5-dibrom-benzol>-sulfonat 
• 83736-02-1 1-(2,5-Dibromo-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one 
• 96108-02-0 p-(2',5'-dibromobenzenesulphonamido)acetophenone 
• 7467-11-0 2,5-dibromobenzenesulfonamide 
• 1071473-28-3 5-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-4-methyl-2-((2,5-dibromophenyl)sulfonylamino)thiazole 
• 1181465-78-0 N-(1-aminoethilidene)-2,5-dibromo-1benzenesulfonamide 
• 40018-42-6 7-bromo-3-phenyl-4H-1,2,4-benzothiadiazine-1,1-dioxide 
• 1310552-60-3 N-amino(phenyl)methylene-2,5-dibromo-1-benzenesulfonamide 
• 1312951-81-7 2-benzenesulfonyl-1,4-dibromobenzene 
• 4163-84-2 1,4-dibromo-2-(methylsulfonyl)benzene 
• 1426901-75-8 C₁₈H₁₆Br₂N₂O₃S 
• 1191926-54-1 1,1-dimethylethyl (3R)-3-{[(2,5-dibromophenyl)sulfonyl]amino}-1-pyrrolidinecarboxylate 
• 942657-49-0 C₁₄H₁₃Br₂NO₃S 

Relevant academic research and scientific papers

LONG WAVELENGTH VOLTAGE SENSITIVE DYES

The disclosure provides for provides for water-soluble near-infra red (NIR) emissive compounds, processes of making the compounds thereof, and use of the compounds therein.

Palladium-Catalysed Desulfitative Heck Reaction Tolerant to Aryl Carbon-Halogen Bonds for Access to (Poly)halo-Substituted Stilbene or Cinnamate Derivatives

The palladium-catalysed desulfitative Heck type reaction of (poly)halo-substituted benzenesulfonyl chlorides with alkenes was investigated. Styrene or acrylates in the presence of bromo- or iodobenzenesulfonyl chlorides and a phosphine-free palladium catalyst were found to afford the expected β-arylated Heck type products with complete regio- and stereoselectivities. The reaction tolerates a variety of substituents on the halobenzenesulfonyl chloride. Moreover, no cleavage of the C-Br and C-I bonds was observed in the course of these reactions, allowing further transformations. Using 4-bromobenzenesulfonyl chloride as the central unit, consecutive desulfitative Heck type reaction followed by palladium-catalysed direct arylation allowed to prepare heteroarylated stilbene derivatives in only two steps.

POLYARYLENE POLYMERS AND PROCESSES FOR PREPARING

Provided are sulfone-containing polyarylene polymers. Also provided are monomers and processes for preparing the polymers. The polyarylene polymers are suitable for use as engineering polymers.

Synthesis and SAR studies of a novel class of S1P1 receptor antagonists

A series of Sodium 4-[(4-butoxyphenyl)thio]-2′-substituted-1,1′-biphenyl-3- sulfonates were identified as functional sphingosine-1-phosphate (S1P) antagonists with selectivity for the S1P1 receptor subtype starting from chemical lead 2, which w