1426916-23-5

Basic information

• Product Name: C₂₄H₂₃F₇N₄O₂
• CAS NO: 1426916-23-5
• Molecular Weight: 532.461
• Mol File: 1426916-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₃F₇N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₃F₇N₄O₂(1426916-23-5)
• EPA Substance Registry System: C₂₄H₂₃F₇N₄O₂(1426916-23-5)

Safety Data

• Hazardous Substances Data: 1426916-23-5(Hazardous Substances Data)

Upstream product

• 1258012-94-0 tert-butyl (2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4,5]decan-8-yl)ethyl)carbamate 
• 393-82-8 2,5-bis(trifluoromethyl)benzoyl chloride 
• 1244639-63-1 8-benzyl-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one 
• 1244639-58-4 1-benzyl-4-((3-fluorophenyl)amino)piperidine-4-carboxamide 
• 97861-33-1 1-(3-fluorophenyl)-1,3,8-triazaspiro<4.5>decan-4-one 
• 372-19-0 meta-fluoroaniline 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Relevant articles and documents

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: Discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells

An iterative parallel synthesis effort identified a PLD2 selective inhibitor, ML298 (PLD1 IC50 > 20 000 nM, PLD2 IC50 = 355 nM) and a dual PLD1/2 inhibitor, ML299 (PLD1 IC50 = 6 nM, PLD2 IC50 = 20 nM). SAR studies revealed that a small structural change (incorporation of a methyl group) increased PLD1 activity within this classically PLD2-preferring core and that the effect was enantiospecific. Both probes decreased invasive migration in U87-MG glioblastoma cells.