1426923-75-2Relevant academic research and scientific papers
Dual behavior of isatin-based cyclic ketimines with dicarbomethoxy carbene: Expedient synthesis of highly functionalized spirooxindolyl oxazolidines and pyrrolines
Rajasekaran,Karthik,Sridhar,Subba Reddy
supporting information, p. 1512 - 1515 (2013/06/26)
A highly stereo-, regio-, and chemoselective method has been devised for the synthesis of a wide range of spirooxindolyl oxazolidines via an intermolecular 1,3-dipolar cycloaddition of carbonyl ylides generated from dimethyl diazomalonate and aromatic aldehydes, with cyclic ketimines using 5 mol % of Rh2(OAc)4 under mild conditions. Similarly, highly functionalized spirooxindolyl pyrrolines have also been prepared through 1,3-dipolar cycloaddition of azomethine ylides generated from dimethyl diazomalonate and cyclic ketimines, with dimethyl acetylenedicarboxylate.
