1426932-16-2Relevant articles and documents
Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of gem-Diborylalkanes to Isatins
Chen, Fen-Er,Li, Hong-Yan,Xiao, You-Cai,Xiong, Tong,Zhou, Li-Yan,Zhou, Yuan
supporting information, p. 791 - 796 (2022/01/28)
The catalytic asymmetric synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins is disclosed. Chiral 3-hydroxyoxindoles bearing two contiguous stereogenic centers were produced in up to >20:1 dr and 99% ee. The synthetic utility of the corresponding products is presented through several transformations of the boryl moiety. This report provides an efficient strategy to incorporate a boryl functional group toward the synthesis of 3-hydroxyoxindoles.