1426945-97-2Relevant academic research and scientific papers
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors
Zhao, Guohua,Kwon, Chet,Wang, Aiying,Robertson, James G.,Marcinkeviciene, Jovita,Parker, Rex A.,Kirby, Mark S.,Hamann, Lawrence G.
, p. 1622 - 1625 (2013/04/10)
Synthesis and structure-activity relationship of a series of substituted piperidinyl glycine 2-cyano-4,5-methano pyrroline DPP-IV inhibitors are described. Improvement of the inhibitory activity and chemical stability of this series of compounds was respectively achieved by the introduction of bulky groups at the 4-position and 1-position of the piperidinyl glycine, leading to a series of potent and stable DPP-IV inhibitors.
