14270-40-7

Upstream product

• 3120-74-9 4-(methylthio)-m-cresol 
• 14143-27-2 3-Methyl-4-methylthio-phenylacetat 
• 14143-28-3 3-methyl-4-(methylsulfinyl)phenol 
• 14086-35-2 fenthion oxon sulfone 
• 70611-05-1 4-amino-2-methylphenyl methyl sulphide 

Downstream Products

• 28253-72-7 Thiophosphoric acid O-ethyl ester O'-(4-methanesulfonyl-3-methyl-phenyl) ester O''-(2-methoxy-1-methyl-ethyl) ester 
• 28253-73-8 Thiophosphoric acid O-(1-chloromethyl-2-methoxy-ethyl) ester O'-(4-methanesulfonyl-3-methyl-phenyl) ester O''-methyl ester 
• 28253-75-0 Thiophosphoric acid O-(3-ethoxy-propyl) ester O'-ethyl ester O''-(4-methanesulfonyl-3-methyl-phenyl) ester 
• 31972-44-8 (1-methylethyl)phosphoramidic acid ethyl 3-methyl-4(methylsulfonyl)phenyl ester 
• 57728-91-3 4-[(trifluoromethyl)sulfonyl]oxy-2-methyl-(methylsulfonyl)benzene 
• 65933-40-6 1-[(1,1-DIMETHYL-2-PHENOXYETHYL)AMINO]-3-[4-(METHYLSULFONYL)-m-TOLYLOXY]-2-PROPANOL 
• 64570-20-3 2-(4-methanesulfonyl-3-methyl-phenoxymethyl)-1-methyl-5-nitro-1H-imidazole 
• 1447121-59-6 1-((3-isopropyl-1,2,4-oxadiazol-5-yl)methyl)-N-methyl-N-(2-(3-methyl-4-(methylsulfonyl)phenoxy)ethyl)piperidine-4-amine 
• 1134197-91-3 5-methyl-4-(methylsulfonyl)-2-nitrophenol 
• 20945-59-9 2,6-Dibromo-4-methanesulfonyl-3-methyl-phenol 
• 28253-74-9 Thiophosphoric acid O-(2-ethoxy-1-methoxymethyl-ethyl) ester O'-ethyl ester O''-(4-methanesulfonyl-3-methyl-phenyl) ester 

Relevant academic research and scientific papers

SUBSTITUTED PIPERIDINE DERIVATIVES AND METHODS FOR PREPARING THE SAME

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, a preparation method thereof and a pharmaceutical composition for treating metabolism-related disorder containing the same. Specifically, the present invention relates to a compound of the formula 1, which can activate GPR119 to treat metabolism-related disorders, including diabetes and related diseases, diabetes-related microvascular complications, diabetes-related macrovascular complications, cardiovascular abnormalities, metabolic syndrome and its constituent diseases, and obesity.

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.

Chromium(VI) oxide catalyzed oxidation of sulfides to sulfones with periodic acid

A highly efficient and selective oxidation of sulfides to sulfones with periodic acid catalyzed by CrO3 is described. A variety of electron-rich and electron-deficient sulfides were oxidized to sulfones with 2 mol% CrO3 in acetonitrile at room temperature in excellent yields. Sulfides with other readily oxidized functional groups were selectively oxidized to sulfones in high yields with 10 mol% CrO3 in ethyl acetate/acetonitrile at -35 °C.

Hydrolysis kinetics of fenthion and its metabolites in buffered aqueous media

This study investigates the hydrolysis kinetics of fenthion and its five oxidation metabolites in pH 7 and pH 9 buffered aqueous media at 25, 50, and 65 °C. Five metabolites and three hydrolysis products were synthesized and purified. The reactant and the corresponding hydrolysis products were determined by HPLC. Rate constant and half-life studies revealed that fenthion and its metabolites were relatively stable in neutral media, and their stability decreased as pH increased. The half-lives at 25 °C ranged from 59.0 days for fenthion to 16.5 days for fenoxon sulfone at pH 7, and from 55.5 days for fenthion to 9.50 days for fenoxon sulfone at pH 9; half- lives were greatly reduced at elevated temperatures. The activation energy (E(a)) was found to range from 16.7 to 22.1 kcal/mol for the compounds investigated. The phenol hydrolysis product of fenthion and fenoxon, 3- methyl-4-methylthiophenol was not stable in pH 7 and pH 9 buffered solutions at 50 °C, whereas 3-methyl-4-methylsulfonylphenol and 3-methyl-4- methylsulfinylphenol were relatively stable under the same conditions. At pH 9, the primary hydrolysis mechanisms of fenthion and its oxidation metabolites were combination of hydroxide ion and neutral water molecule attacking on the P atom to form corresponding phenol derivatives. Under neutral conditions, the primary hydrolysis mechanisms of fenthion and its oxidation metabolites were assumed to be the combination of water molecule attacking on the P atom to form phenol derivatives and on the C atom to yield dealkylation products.

11,21-BISPHENYL-19-NORPREGNANE DERIVATIVES

The invention relates to a 11,21-bisphenyl-19-norpregnane derivative of formula I STR1 wherein R 1 is selected from H, halogen, (1-6C) alkoxy, and NR 5 R 6, R 5 and R 6 being independently hydrogen or (1-6C)alkyl or R 5 and R 6 together are (3-6C) alkylen

Selective Sulfur Oxygenation in Phosphoroamidate, Thionophosphate, and Thiophosphate Agrochemicals by Perfluoro-cis-2,3-dialkyloxaziridine

Several organophsophorus agrochemicals 2a-g with thioether, phosphoramidic, phosphorothioic, and phosphorothionic functions were reacted with perfluoro-cis-2-n-butyl-3-n-propyloxaziridine 1.The selective oxygenation of sulfide function to give sulfoxide derivatives 3a-g occured in high yields without overoxidation to sulfone products.Sulfoxides 3a-e were further oxidized under mild conditions to the corresponding sulfones 4a-e.All the products are themselves of interest as analytical environmental standards and their preparation is described in detail.

Physico-Chemical Studies on Some Alkylmercapto- and Alkylsulphonyl Phenols

Electric dipole moments, dissociation constants and uv absorption spectra have been determined for two alkylmercapto phenols and two alkylsulphonyl phenols.The results are examined with a view to ascertaining whether or not the 3d orbitals of the sulphur atom participate in resonance.