3120-74-9Relevant articles and documents
A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2andtBuOK
Pan, Wenjing,Li, Chenchen,Zhu, Haoyin,Li, Fangfang,Li, Tao,Zhao, Wanxiang
, p. 7633 - 7640 (2021/09/22)
A general method for the demethylation, debenzylation, and deallylation of aryl ethers using HPPh2andtBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical method in organic synthesis.
Hydrolysis kinetics of fenthion and its metabolites in buffered aqueous media
Huang, Jiping,Mabury, Scott A.
, p. 2582 - 2588 (2007/10/03)
This study investigates the hydrolysis kinetics of fenthion and its five oxidation metabolites in pH 7 and pH 9 buffered aqueous media at 25, 50, and 65 °C. Five metabolites and three hydrolysis products were synthesized and purified. The reactant and the corresponding hydrolysis products were determined by HPLC. Rate constant and half-life studies revealed that fenthion and its metabolites were relatively stable in neutral media, and their stability decreased as pH increased. The half-lives at 25 °C ranged from 59.0 days for fenthion to 16.5 days for fenoxon sulfone at pH 7, and from 55.5 days for fenthion to 9.50 days for fenoxon sulfone at pH 9; half- lives were greatly reduced at elevated temperatures. The activation energy (E(a)) was found to range from 16.7 to 22.1 kcal/mol for the compounds investigated. The phenol hydrolysis product of fenthion and fenoxon, 3- methyl-4-methylthiophenol was not stable in pH 7 and pH 9 buffered solutions at 50 °C, whereas 3-methyl-4-methylsulfonylphenol and 3-methyl-4- methylsulfinylphenol were relatively stable under the same conditions. At pH 9, the primary hydrolysis mechanisms of fenthion and its oxidation metabolites were combination of hydroxide ion and neutral water molecule attacking on the P atom to form corresponding phenol derivatives. Under neutral conditions, the primary hydrolysis mechanisms of fenthion and its oxidation metabolites were assumed to be the combination of water molecule attacking on the P atom to form phenol derivatives and on the C atom to yield dealkylation products.
Physico-Chemical Studies on Some Alkylmercapto- and Alkylsulphonyl Phenols
Shanmuganathan, Sp.,Durai, V.,Sundaravelu, T.
, p. 52 - 54 (2007/10/02)
Electric dipole moments, dissociation constants and uv absorption spectra have been determined for two alkylmercapto phenols and two alkylsulphonyl phenols.The results are examined with a view to ascertaining whether or not the 3d orbitals of the sulphur atom participate in resonance.