1427003-06-2Relevant academic research and scientific papers
Synthesis of medium-sized lactones from siloxy alkynes via ring expansion
Wu, An,Zhao, Wanxiang,Sun, Jianwei
, (2020/04/16)
Synthesis of medium ring lactones remains as a challenging topic in organic synthesis due to the disfavored kinetic and thermodynamic features. Herein we detail an efficient intermolecular process using siloxy alkynes as substrates and oxetene ring expansion as the key strategy. With extension to a new silyl-masked alkyne, this reaction now features a broad scope, high efficiency, and mild conditions.
A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition
Zhao, Wanxiang,Li, Zigang,Sun, Jianwei
, p. 4680 - 4683 (2013/05/09)
We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.
